Multi-laboratory preclinical trials as the standard for go/no-go decisions
Instead of one lab's mouse study deciding whether a drug goes to patients, several labs run the same protocol independently, like a multi-centre clinical trial for mice.
Multi-centre preclinical randomised trials (for example the Multi-PART stroke consortium and EQIPD in Europe) show that effect sizes shrink and heterogeneity appears when protocols are run across sites, exposing fragile findings before they reach patients. In oncology, a standing network of laboratories that runs pre-registered, blinded, multi-site efficacy studies for compounds approaching translation would replace single-lab evidence with robust estimates.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaPre-specified sample sizes for animal studies; no more 'representative' experiments
Shares Audit animal studies for randomisation and blinding, published by institution, Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaHumanised mice with an immune system matched to the tumour donor
Shares Champions Oncology, Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaRun the mouse or organoid trial at the same time as the human trial
Shares Champions Oncology, Patient-derived xenografts, Preclinical models that do not predict people.
- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaPaid independent statistical review for preclinical papers that inform trials
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaShared reference organoid and PDX panels that every lab can test against
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.