Audit animal studies for randomisation and blinding, published by institution
Most mouse studies of cancer drugs do not randomise animals or blind the people measuring tumours, which inflates results. Checking and publishing which institutions do it properly would change behaviour.
The ARRIVE guidelines set minimum reporting standards for animal research, but compliance remains low and unenforced. Systematic reviews show that unblinded, unrandomised animal studies overestimate effects. Funders could commission annual audits of a random sample of animal studies they supported, scoring randomisation, blinding, sample-size justification and reporting, and publish scores by institution.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaTop journals require an independent lab to reproduce key findings before publication
Shares Multi-laboratory preclinical trials as the standard for go/no-go decisions, Preclinical results do not reproduce.
- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- CompanyChampions Oncology
Shares Multi-laboratory preclinical trials as the standard for go/no-go decisions, Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaProve the cell line is what you say it is, or the paper does not run
Shares Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaShared reference organoid and PDX panels that every lab can test against
Shares Patient-derived xenografts, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaAn independent replication institute that re-tests key preclinical cancer findings before trials
Shares Patient-derived xenografts, Preclinical results do not reproduce.