ADC bioconjugation manufacturing (CDMOs)
Joining a highly toxic payload to an antibody safely and at scale. Few contractors can do it, which shapes who can develop ADCs.
ADC manufacturing needs high-potency containment (OEB 5), conjugation chemistry, and analytics for drug-to-antibody ratio and free payload. Capacity is concentrated in a handful of CDMOs: Lonza (Visp, incl. Synaffix technology), WuXi XDC, Samsung Biologics (new ADC plant 2025), Piramal Pharma Solutions, Abzena, Sterling, and Merck KGaA's MilliporeSigma. Payload-linker supply (MedChemExpress, Levena, Kelun's in-house) and lyophilised fill-finish are the other choke points.
How it works
Antibody produced by CHO cell culture; payload-linker synthesised under containment; site-specific or stochastic conjugation, purification, and DAR analytics; aseptic fill.
- Specialised containment and analytics
- Integrated antibody-to-vial programmes
- Few qualified sites, long queues
- Geopolitical exposure (China-based capacity)
- Payload-linker single sourcing
Latest papers
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Pages like this
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Shares Samsung Biologics, CDMO (contract development and manufacturing organisation), Lonza, Antibody manufacturing (CHO bioprocessing) and the tag supporting.
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Shares CDMO (contract development and manufacturing organisation), Lonza and the tag supporting.
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Shares BIOSECURE Act and the tag supporting.
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Shares Antibody manufacturing (CHO bioprocessing) and the tag supporting.
- CompanyFUJIFILM Diosynth Biotechnologies
Shares Antibody manufacturing (CHO bioprocessing) and the tag supporting.
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Shares BIOSECURE Act and the tag supporting.
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Shares Lonza and the tag supporting.
- IdeaPlatform designation for ADC linker-payloads so manufacturing data carry across
Shares Synaffix (Lonza), Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).