Payload-linker synthesis (high-potency API)
Making the microgram-potent toxins inside ADCs, in facilities built so a speck of dust cannot harm a worker.
Camptothecin derivatives (exatecan, DXd), auristatins (MMAE/MMAF), maytansinoids (DM1/DM4), and PBD dimers are synthesised under OEB 5/6 containment by specialists (Lonza, MilliporeSigma, WuXi STA, Piramal, Sterling, Ajinomoto Bio-Pharma, Levena, Cerbios, Kelun in-house) and sold as ready-to-conjugate linker-payloads. Supply is a gating factor for the hundreds of ADCs in development.
How it works
Multi-step synthesis and purification of cytotoxic small molecules and linkers under engineered containment, with occupational exposure limits in the nanogram range.
- Standardised, reusable linker-payload building blocks
- Few licensed sites
- Long lead times
- IP encumbrance on best payloads
Latest papers
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Pages like this
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