Train the bone marrow to make better anti-tumour immune cells
Certain vaccines and fungal sugars reprogramme the bone marrow so it produces more aggressive immune cells for months. That could be used before immunotherapy.
Trained immunity — epigenetic reprogramming of haematopoietic progenitors by BCG or beta-glucan — produces durable changes in myeloid output and reduced tumour growth in mouse models, and BCG's efficacy in bladder cancer is the oldest immunotherapy in use. Priming the marrow before checkpoint therapy or cell therapy is a cheap, generic intervention that has never been formally tested in solid tumours.
- Cold tumours and the immunosuppressive microenvironment · Most tumours keep the immune system out or asleep, so immunotherapy helps only a minority.
- No incentive to repurpose cheap drugs · Old, cheap drugs with anti-cancer signals never get the trials they need because no one profits from the result.
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not linked directly; found by shared links- IdeaEngineered bacteria that live in tumours and manufacture drugs there
Shares Intravesical BCG, Intravesical therapy (BCG, chemotherapy, devices, gene and viral therapy), Cold tumours and the immunosuppressive microenvironment, Colorectal cancer.
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Shares Hot vs cold tumours, No incentive to repurpose cheap drugs, Cold tumours and the immunosuppressive microenvironment, Immune checkpoint inhibitors.
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Shares Intravesical BCG, Intravesical therapy (BCG, chemotherapy, devices, gene and viral therapy), Bladder & urothelial cancer.
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Shares Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, Immune checkpoint inhibitors, Colorectal cancer.
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Shares Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, Immune checkpoint inhibitors, Colorectal cancer.
- TechnologyTrained innate immunity
Shares Intravesical therapy (BCG, chemotherapy, devices, gene and viral therapy), Bladder & urothelial cancer, Immune checkpoint inhibitors.
- PairingDurvalumab + BCG in BCG-naive high-risk NMIBC
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Shares Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, Bladder & urothelial cancer, Immune checkpoint inhibitors.