Envafolimab
Envafolimab is the first PD-L1 antibody given as a quick injection under the skin rather than an infusion, approved in China for advanced tumours with mismatch-repair deficiency.
Overview
Approved by the NMPA in November 2021 for previously treated MSI-H or dMMR advanced solid tumours, on a single-arm study across colorectal and other cancers, the first subcutaneous PD-(L)1 antibody approved anywhere. Developed by Alphamab Oncology with 3D Medicines in China; TRACON Pharmaceuticals held North American rights for a sarcoma programme that did not succeed. Its convenience rather than potency is the point: a 30-second injection in a country where infusion chairs are scarce outside big cities.
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Approvals
| Region | Year | Indication |
|---|---|---|
| China | 2021 | Previously treated MSI-H or dMMR advanced solid tumours |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Envafolimab" OR ABSTRACT:"Envafolimab" OR TITLE:"Enweida" OR ABSTRACT:"Enweida" OR TITLE:"KN035" OR ABSTRACT:"KN035") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Envafolimab, not a curated reading list.
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