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Living with cancer· Appointment prep

Appointment sheet: p53-abnormal endometrial cancer, including uterine serous carcinoma

One page to bring and write on: your details, the questions for p53-abnormal endometrial cancer, including uterine serous carcinoma plus your own, the words you may hear, what to bring, the treatments the standard of care names, and room for the answers and agreed next steps. What you type stays in this browser. Print it or save it as a PDF. New to all this? Start with the first 60 days. Orientation, not medical advice.

Tick the questions to print

All of this cancer's questions start ticked. Untick what does not apply; ticks are kept in this browser. .

Your own questions

Shared with the prep pack, so questions you add there appear here too.

Print or save as PDF

Use (or Ctrl+P, Cmd+P on a Mac). To keep a copy, choose Save as PDF as the destination in the print dialog. Only the sheet prints; the controls stay on screen. Your typed notes print where you typed them; empty fields print as ruled lines to write on.

Appointment sheet

p53-abnormal endometrial cancer, including uterine serous carcinoma

Prepared with OnCo (onco.cc/prep/endometrial-p53-abnormal/). Orientation, not medical advice; your team knows your case.

My details

Name
Date of appointment
Hospital and clinician
Who is coming with me

What I know, what is unclear, changes to discuss

Saved in this browser
What I know so far
What is unclear to me
Changes since last time

My questions

19 on the sheet
Newly diagnosed
  1. 1.What is my exact diagnosis, stage, and grade, and which tests established them?
  2. 2.Which biomarkers have been tested on my tumour (for example p53 immunohistochemistry, TP53 sequencing where staining is equivocal, HER2 immunohistochemistry and in situ hybridisation, Copy-number burden and homologous recombination deficiency, CA-125 for monitoring), and what were the results?
  3. 3.Which subtype is my cancer, and does that change the recommended treatment?
  4. 4.Is germline (inherited) genetic testing recommended for me or my family?
Surgery and staging
  1. 5.For my situation (surgery and staging), which of the standard options do you recommend and why?
Adjuvant, stage I to III
  1. 6.For my situation (adjuvant, stage i to iii), which of the standard options do you recommend and why?
  2. 7.Am I a candidate for Carboplatin, Paclitaxel / nab-paclitaxel, and what side effects should I expect?
  3. 8.How do the results of PORTEC-3 apply to someone like me?
Advanced or recurrent HER2-positive serous
  1. 9.For my situation (advanced or recurrent her2-positive serous), which of the standard options do you recommend and why?
  2. 10.Am I a candidate for Trastuzumab, Trastuzumab deruxtecan, and what side effects should I expect?
  3. 11.How do the results of DESTINY-PanTumor02 apply to someone like me?
Advanced or recurrent HER2-negative
  1. 12.For my situation (advanced or recurrent her2-negative), which of the standard options do you recommend and why?
  2. 13.Am I a candidate for Carboplatin, Paclitaxel / nab-paclitaxel, Dostarlimab or related drugs, and what side effects should I expect?
  3. 14.How do the results of RUBY / ENGOT-EN6 / GOG-3031 and KEYNOTE-775 / Study 309 apply to someone like me?
Any stage
  1. 15.Are there clinical trials I could join, for example of DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC, Trastuzumab deruxtecan, Olaparib, HER2 ADCs as standard for HER2-positive serous endometrial cancer?
  2. 16.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
  3. 17.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
  4. 18.I read that “Distant relapse after early-stage disease despite chemotherapy”. How does that affect my plan?
  5. 19.I read that “Whether PARP inhibition helps p53-abnormal tumours as it does ovarian cancer”. How does that affect my plan?

The words I may hear

Tests and results to bring

Surgery and staging: Hysterectomy with bilateral salpingo-oophorectomy, sentinel node mapping and omental sampling, with peritoneal assessment because serous tumours spread like ovarian cancer.

Biomarker results to ask for: p53 immunohistochemistry (mutant-pattern staining or null), TP53 sequencing where staining is equivocal, HER2 immunohistochemistry and in situ hybridisation (serous and carcinosarcoma), Copy-number burden and homologous recombination deficiency, CA-125 for monitoring, PIK3CA, PPP2R1A and FBXW7 mutations.

Scans and tests linked to this cancer: Histopathology & immunohistochemistry.

Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.

The treatments I may be offered

From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.

Answers and next steps

Saved in this browser
What I was told
Agreed next steps, dates and who to call