Adenosquamous and squamous carcinoma of the gallbladder
Prepared with OnCo (onco.cc/prep/gallbladder-adenosquamous-squamous-carcinoma/). Orientation, not medical advice; your team knows your case.
My details
What I know, what is unclear, changes to discuss
Saved in this browserMy questions
8 on the sheet- 1.What is my exact diagnosis, stage, and grade, and which tests established them?
- 2.Which biomarkers have been tested on my tumour (for example Share of squamous component, Grade, T categoryand node status, PD-L1 combined positive score, Claudin 18.2), and what were the results?
- 3.Which subtype is my cancer, and does that change the recommended treatment?
- 4.Is germline (inherited) genetic testing recommended for me or my family?
- 5.For my situation (all stages), which of the standard options do you recommend and why?
- 6.Am I a candidate for Gemcitabine + cisplatin, and what side effects should I expect?
- 7.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
- 8.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
The words I may hear
- Squamous cell carcinoma: A carcinoma arising from the flat, layered cells that line surfaces exposed to wear: skin, mouth, throat, oesophagus, cervix, the larger airways.
- Radical (extended) cholecystectomy: The cancer operation for gallbladder cancer: the gallbladder (if still present) is removed together with a rim of the liver it sits against and the lymph nodes along the bile duct and liver blood vessels.
- Grade: How abnormal the cancer cells look under the microscope, from grade 1 (close to normal, slow) to grade 3 or 4 (wildly abnormal, fast).
- Chemoradiation (chemoradiotherapy, CRT): Radiotherapy given at the same time as chemotherapy, which sensitises the cancer to radiation.
Tests and results to bring
Biomarker results to ask for: Share of squamous component (25 percent threshold), Grade, T category (usually T3 or T4 at presentation) and node status, PD-L1 combined positive score (above 1 in 96 percent of one cohort), Claudin 18.2 (28 percent of one cohort).
Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.
The treatments I may be offered
- All stages: As for gallbladder adenocarcinoma; complete resection is the only setting with long-term survivors in the surgical series, and adjuvant chemoradiation was associated with benefit in the National Cancer Database. (Gallbladder adenocarcinoma, Radical (extended) cholecystectomy, Chemoradiation (chemoradiotherapy, CRT), Gemcitabine + cisplatin)
From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.