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Living with cancer· Appointment prep

Appointment sheet: HER2-amplified colorectal cancer

One page to bring and write on: your details, the questions for HER2-amplified colorectal cancer plus your own, the words you may hear, what to bring, the treatments the standard of care names, and room for the answers and agreed next steps. What you type stays in this browser. Print it or save it as a PDF. New to all this? Start with the first 60 days. Orientation, not medical advice.

Tick the questions to print

All of this cancer's questions start ticked. Untick what does not apply; ticks are kept in this browser. .

Your own questions

Shared with the prep pack, so questions you add there appear here too.

Print or save as PDF

Use (or Ctrl+P, Cmd+P on a Mac). To keep a copy, choose Save as PDF as the destination in the print dialog. Only the sheet prints; the controls stay on screen. Your typed notes print where you typed them; empty fields print as ruled lines to write on.

Appointment sheet

HER2-amplified colorectal cancer

Prepared with OnCo (onco.cc/prep/her2-amplified-colorectal/). Orientation, not medical advice; your team knows your case.

My details

Name
Date of appointment
Hospital and clinician
Who is coming with me

What I know, what is unclear, changes to discuss

Saved in this browser
What I know so far
What is unclear to me
Changes since last time

My questions

18 on the sheet
Newly diagnosed
  1. 1.What is my exact diagnosis, stage, and grade, and which tests established them?
  2. 2.Which biomarkers have been tested on my tumour (for example HER2 immunohistochemistry 3+, or 2+ with in situ hybridisation amplification, ERBB2 copy number on tumour or circulating tumour DNA sequencing, RAS and BRAF wild-type status, Left-sided or rectal primary), and what were the results?
  3. 3.Which subtype is my cancer, and does that change the recommended treatment?
  4. 4.Is germline (inherited) genetic testing recommended for me or my family?
Metastatic, RAS wild-type, previously treated
  1. 5.For my situation (metastatic, ras wild-type, previously treated), which of the standard options do you recommend and why?
  2. 6.Am I a candidate for Tucatinib, Trastuzumab, Pertuzumab, and what side effects should I expect?
  3. 7.How do the results of MOUNTAINEER & MOUNTAINEER-03 apply to someone like me?
After HER2 antibodies, or with RAS mutation
  1. 8.For my situation (after her2 antibodies, or with ras mutation), which of the standard options do you recommend and why?
  2. 9.Am I a candidate for Trastuzumab deruxtecan, and what side effects should I expect?
  3. 10.How do the results of DESTINY-CRC02 apply to someone like me?
Metastatic, first line
  1. 11.For my situation (metastatic, first line), which of the standard options do you recommend and why?
  2. 12.Am I a candidate for FOLFOX (5-FU, leucovorin, oxaliplatin), FOLFIRI (5-FU, leucovorin, irinotecan), Bevacizumab, and what side effects should I expect?
  3. 13.How do the results of A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer apply to someone like me?
Any stage
  1. 14.Are there clinical trials I could join, for example of A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer, Zanidatamab, A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors, TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer?
  2. 15.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
  3. 16.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
  4. 17.I read that “No randomised evidence yet for HER2 blockade in first line”. How does that affect my plan?
  5. 18.I read that “RAS co-mutation blunts dual HER2 blockade and the best option for those patients is unclear”. How does that affect my plan?

The words I may hear

Tests and results to bring

Biomarker results to ask for: HER2 immunohistochemistry 3+, or 2+ with in situ hybridisation amplification, ERBB2 copy number on tumour or circulating tumour DNA sequencing, RAS and BRAF wild-type status (predicts response to dual HER2 blockade), Left-sided or rectal primary.

Scans and tests linked to this cancer: Histopathology & immunohistochemistry.

Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.

The treatments I may be offered

From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.

Answers and next steps

Saved in this browser
What I was told
Agreed next steps, dates and who to call