DRd (daratumumab + lenalidomide + dexamethasone)
Checked 2026-09-09
Newly diagnosed transplant-ineligible myeloma (MAIA); relapsed myeloma (POLLUX)
One cycle
every 28 daysComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Daratumumab Monoclonal antibody (anti-CD38) | 16 mg/kg IV or 1,800 mg SC: weekly cycles 1-2, every 2 weeks cycles 3-6, then every 4 weeks | SC | D1, 8, 15, 22 | |
Lenalidomide Immunomodulatory drug (cereblon E3 ligase modulator) | 25 mg once daily | Oral | D1-21 | |
Dexamethasone | 40 mg weekly (20 mg over 75 years) | Oral | D1, 8, 15, 22 |
Cycles
until progression
28-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine
Used in
Products
Source
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.
Other regimens for these cancers
Pegylated liposomal doxorubicin
Platinum-resistant or partially platinum-sensitive ovarian cancer; Kaposi sarcoma
every 28 days
VRd
Newly diagnosed myeloma (with daratumumab as D-VRd in transplant-eligible patients)
every 21 days × 8
D-VRd (PERSEUS)
Newly diagnosed transplant-eligible myeloma: 4 induction cycles, ASCT, 2 consolidation cycles, then D-R maintenance
every 28 days × 4
High-dose melphalan and autologous stem-cell transplant
Transplant-eligible myeloma after induction
single day × 1
Lenalidomide maintenance
After autologous transplant
every 28 days
Teclistamab
Relapsed or refractory myeloma after 3 or more lines including a PI, IMiD and CD38 antibody
weekly