JEB (carboplatin, etoposide, bleomycin)
Checked 2026-09-09
Malignant extracranial germ cell tumours in children (UK Children's Cancer Study Group), a carboplatin-based alternative to cisplatin regimens
Also called JEB.
One cycle
every 21 days × 4-6 · about 12 weeks in totalComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Carboplatin Cytotoxic chemotherapy (platinum) | 600 mg/m² (or dosed to GFR) | IV | D2 | |
Etoposide Topoisomerase II inhibitor (podophyllotoxin derivative) | 120 mg/m² | IV | D1-3 | |
Bleomycin Glycopeptide antibiotic (DNA-cleaving) | 15 mg/m² | IV | D3 |
Cycles
4-6 (two beyond marker normalisation)
21-day cycle
Emetogenicity
High (>90%)
G-CSF
Not routine
Notes
- Carboplatin replaced cisplatin to spare children's hearing and kidneys, with cure rates comparable to cisplatin-based regimens in this study.
- Bleomycin is given once per cycle, less often than in adult BEP.
Used in
Products
Source
Mann (UKCCSG GC2), JCO 2000: carboplatin, etoposide and bleomycin for children's germ cell tumours
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.