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Cancers & treatments·Regimen libraryChemoradiation

Mitomycin + fluorouracil chemoradiation

Checked 2026-09-09

Localised anal squamous cell carcinoma, definitive treatment

Also called Nigro regimen.

One cycle

every 56 days × 1 · about 8 weeks in total
17814152122282935364243495056Mitomycin: 10 mg/m² (maximum 20 mg), IntravenousMitomycinFluorouracil infusion: 1,000 mg/m² per day, IntravenousFluorouracil infusionRadiotherapy: 50.4-54 Gy in 28-30 fractions, RadiotherapyRadiotherapy
56-day cycle × 1 (two chemotherapy pulses across 5-6 weeks of radiotherapy) (about 8 weeks)IntravenousRadiotherapy Continuous infusion

Components

DrugDoseRouteDays
Mitomycin
Alkylating antibiotic (bioreductive)
10 mg/m² (maximum 20 mg)IVD1, 29
Fluorouracil infusion
Fluoropyrimidine antimetabolite
1,000 mg/m² per dayIVD1, 2, 3, 4, 29, 30, 31, 32 (96 h infusion)
Radiotherapy
50.4-54 Gy in 28-30 fractionsRadiotherapyD1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 22, 23, 24, 25, 26, 29, 30, 31, 32, 33, 36, 37, 38, 39, 40
Cycles
1 (two chemotherapy pulses across 5-6 weeks of radiotherapy)
56-day cycle
Emetogenicity
Moderate (30-90%)
G-CSF
Not routine

Used in

Anal cancer (squamous cell carcinoma)
Products
Mitomycin CFluorouracil (5-FU)

Source

RTOG 98-11, JAMA 2008

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.

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