Adolescent and young adult cancers (ages 15 to 39): lines of therapy

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5 standard-of-care settings across 2 lines and 2 biomarker subgroups. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

Line	All comers	HR-positive
Special situations	·	1
Other settings	4	·

Special situations

Subgroup	Setting	Approach	Products and trials	Guideline	Evidence
HR-positive	Survivorship	Treatment summary and risk-based follow-up for cardiac, second-cancer, endocrine and fertility late effects over decades.	Survivorship care and late-effects surveillanceLate effects and survivorship toxicityCardio-oncologyA survivorship passport app for adolescent and young adult survivorsChildhood Cancer Survivor Study (CCSS)	NCI: Adolescents and Young Adults with Cancer	79

Other settings

Subgroup	Setting	Approach	Products and trials	Guideline	Evidence
All comers	Acute lymphoblastic leukaemia, 15 to 39	Paediatric-inspired regimen with asparaginase (CALGB 10403 model) and blinatumomab consolidation for MRD-negative B-ALL (E1910); Ph-like screening at diagnosis.	Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase)VincristineDexamethasoneMethotrexateBlinatumomabECOG-ACRIN E1910NGS-based MRD (clonoSEQ and molecular MRD)ECOG-ACRIN E1910: adding blinatumomab to chemotherapy for adults with B-cell ALL already in MRD-negative remission	NCI: Adolescents and Young Adults with Cancer	93
All comers	Before any gonadotoxic treatment	Fertility preservation referral (sperm banking, oocyte or embryo cryopreservation, ovarian tissue) as a default step.	Oncofertility and fertility preservation	NCI: Adolescents and Young Adults with Cancer	32
All comers	Psychosocial and financial	Age-specific units or teams, distress screening, education and employment support, financial navigation.	Psycho-oncology and distress screeningFinancial toxicityTeenage Cancer Trust	NCI: Adolescents and Young Adults with Cancer	32
All comers	Hereditary risk	Germline testing in young-onset breast, colorectal, sarcoma and other cancers, with cascade testing of relatives.	Germline (hereditary) testing	NCI: Adolescents and Young Adults with Cancer	94

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.