OnCo

Craniopharyngioma: lines of therapy

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4 standard-of-care settings across 3 lines and 3 biomarker subgroups. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

LineAll comersBRAFHR-positive
Advanced, first line··1
Special situations1··
Other settings11·

Advanced, first line

SubgroupSettingApproachProducts and trialsEvidence
HR-positiveNewly diagnosed, no or limited hypothalamic involvementGross total resection (transsphenoidal or craniotomy) with endocrine replacement; observation with serial MRI.40

Special situations

SubgroupSettingApproachProducts and trialsEvidence
All comersSurvivorshipLifelong endocrinology follow-up, management of hypothalamic obesity, sleep and behavioural sequelae; structured survivorship care.58

Other settings

SubgroupSettingApproachProducts and trialsEvidence
All comersHypothalamic involvementHypothalamus-sparing subtotal resection or cyst drainage followed by conformal or proton radiotherapy; intracystic therapy for predominantly cystic tumours.91
BRAFPapillary craniopharyngioma, BRAF V600EBRAF plus MEK inhibition (vemurafenib-cobimetinib per Alliance A071601, or dabrafenib-trametinib) before or instead of extensive surgery; radiotherapy after response.84

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.