OnCo

Parathyroid carcinoma: lines of therapy

Cancer page →

3 standard-of-care settings across 3 lines and 1 biomarker subgroup. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

LineAll comers
Early / localised1
Advanced, first line1
Other settings1

Early / localised

SubgroupSettingApproachProducts and trialsEvidence
All comersSuspected or confirmed carcinoma, resectableEn bloc resection with ipsilateral thyroid lobectomy and removal of adherent tissue, avoiding capsule rupture; re-resection for loco-regional recurrence.

Advanced, first line

SubgroupSettingApproachProducts and trialsEvidence
All comersHypercalcaemia, unresectable or metastatic diseaseCinacalcet titrated to calcium, denosumab or intravenous bisphosphonate, hydration; palliative resection or ablation of metastases to reduce PTH burden.86

Other settings

SubgroupSettingApproachProducts and trialsEvidence
All comersAll patientsGermline CDC73 testing and family counselling; surveillance for jaw and renal tumours in carriers.94

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.