histiocytosis
No description yet: the sentence for this tag has not been written. 2 records carry it: 1 cancer, 1 trial.
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2 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
Erdheim-Chester disease, Rosai-Dorfman disease and other histiocytic neoplasms Histiocytoses are diseases in which immune scavenger cells build up in bone, heart, brain, kidneys and skin. They used to be treated as inflammatory conditions with steroids and interferon. The discovery that most carry mutations in the same growth pathway as melanoma turned them into targetable cancers: BRAF and MEK inhibitor pills now produce responses in nearly every treated patient. | none | none | rare, haematologic | ||
LCH-III NCT00276757 The Histiocyte Society's third international trial showed that treating multisystem Langerhans cell histiocytosis for a full year, rather than six months, roughly halves the chance of the disease coming back, while adding methotrexate added nothing but toxicity. | Langerhans cell histiocytosis, Multisystem Langerhans cell histiocytosis, Single-system Langerhans cell histiocytosis | paediatric |