hormone-receptor
No description yet: the sentence for this tag has not been written. 3 records carry it: 3 biomarkers.
Related tags
3 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
ER status (oestrogen receptor by IHC) ESR1 ER status is whether the tumour's cells carry the oestrogen receptor, read by staining nuclei. One percent or more of stained nuclei is positive and means hormone-blocking treatment can work; 1 to 10 percent is 'low positive' and behaves more like negative. | HR-positive / HER2-negative breast cancer, Breast cancer, High-risk early HR-positive breast cancer | none | biomarker | ||
ESR1 mutation (ligand-binding domain, usually in ctDNA) ESR1 ESR1 mutations arise in the oestrogen receptor's ligand-binding domain after aromatase inhibitor treatment, letting the receptor work without oestrogen. They are usually found in a blood test and select the oral SERDs elacestrant and imlunestrant. | HR-positive / HER2-negative breast cancer, HR-positive metastatic breast cancer after CDK4/6 inhibitors | none | biomarker, resistance | ||
PR status (progesterone receptor by IHC) PGR PR status is read the same way as ER: 1 percent or more of nuclei staining is positive. It is measured alongside ER, adds to prognosis, and a tumour positive for either receptor counts as hormone-receptor-positive. | HR-positive / HER2-negative breast cancer, Breast cancer, Endometrial cancer | none | biomarker |