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No description yet: the sentence for this tag has not been written. 7 records carry it: 5 technologies, 1 bottleneck, 1 idea.
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
B-cell aplasia and low antibodies after CAR-T and bispecifics, and immunoglobulin replacement Treatments aimed at a protein on B cells cannot tell a cancerous B cell from a healthy one, so they remove both, antibody levels fall and infections become more frequent. The fix is to give the antibodies back every few weeks. In one myeloma study, serious infections were ten times less frequent while people were receiving immunoglobulin. | none | none | rejuvenation, survivorship, transplant | ||
Chronic graft-versus-host disease After a donor transplant the new immune system can treat the body it has landed in as foreign. When that goes on past the first few months it is called chronic graft-versus-host disease, and it affects roughly four in ten adults. It is treatable and often improves, and the same donor immunity also keeps the leukaemia away, so the aim is to control it rather than abolish it. | none | none | rejuvenation, survivorship, transplant | ||
Find out whether an adult thymus can be made to work again, with an endpoint a clinician would act on Several agents have been tried for thymic recovery after transplant and none is in routine use. The blocker is as much the missing endpoint as the missing drug. | none | none | rejuvenation, survivorship, open-problem | ||
Infection risk after transplant and cell therapy, phase by phase, and the prophylaxis that follows it Which infections threaten someone after a transplant depends almost entirely on how long it has been, because the immune system returns in a known order: bacteria and fungi first, viruses such as cytomegalovirus in the middle months, encapsulated bacteria later. The preventive medicines are matched to those phases. | none | none | rejuvenation, survivorship, transplant | ||
Nothing in routine use rebuilds an adult's thymus After a transplant or intensive chemotherapy, the part of the immune system that makes new kinds of T cell recovers slowly in adults and sometimes not at all. The deficit is well described, well measured and currently not correctable. | none | none | rejuvenation, survivorship, open-problem | ||
Rebuilding an immune system: the timeline, lineage by lineage After a transplant the immune system comes back in a fixed order, and the order explains most of what follows. Neutrophils in two to four weeks, natural killer cells within a month, B cells over several months to a year, and T cells last and slowest. Adults rebuild a narrower repertoire, because the thymus shrinks with age. | none | none | rejuvenation, survivorship, transplant | ||
Revaccination after transplant: the schedules, and where the UK and the US differ A transplant erases the protection built up by a lifetime of vaccinations, including childhood ones, and it has to be rebuilt. Published schedules exist, the vaccines are free at the point of use in the NHS, and the usual failure is that nobody writes the plan down. If you have had a transplant and have no written schedule, ask for one. | none | rejuvenation, survivorship, transplant |