pet-target
No description yet: the sentence for this tag has not been written. 3 records carry it: 3 targets.
Related tags
3 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
FAP FAP FAP (fibroblast activation protein) sits on the cancer-associated fibroblasts that scaffold more than 90% of epithelial cancers and is almost absent from normal adult tissue. FAPI PET tracers therefore light up tumours with high contrast, including pancreatic, gastric and low-grade cancers where FDG PET is weak, and FAP-targeted radioligands are in development. | Pancreatic ductal adenocarcinoma, Gastric & gastro-oesophageal junction cancer, Triple-negative breast cancer | none | theranostic, stroma | ||
PSMA FOLH1 A protein on prostate cancer cells that lets doctors both see the cancer on a PET scan and hit it with a radioactive drug. | Prostate cancer | none | theranostic | ||
TROP2 TACSTD2 TROP2 is a surface glycoprotein present at high levels on most epithelial cancers (breast, lung, urothelial, gastric, pancreatic) and at low levels on normal tissue. It does not drive the cancer; it is a delivery address, used by the approved ADCs sacituzumab govitecan and datopotamab deruxtecan and by sacituzumab tirumotecan, with a TROP2 PET tracer in development to pick patients. | Triple-negative breast cancer, HR-positive / HER2-negative breast cancer, Non-small-cell lung cancer | none | adc-target |