Acute promyelocytic leukaemia

What changed: Acute promyelocytic leukaemia

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Every dated change on the records linked to Acute promyelocytic leukaemia, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

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September 2026 · 1

2026-09-17This recordAcute promyelocytic leukaemia
Facts on this page last checked
When this page itself was last checked or edited.

2018 · 2

2013 · 1

2013MilestoneTretinoin (all-trans retinoic acid, ATRA)
APL0406: retinoic acid plus arsenic beats retinoic acid plus chemotherapy
A milestone in how this cancer is treated.

2002 · 1

2002ApprovalArsenic trioxide
Arsenic trioxide approved in EU
APL

2000 · 2

1995 · 1

1995ApprovalTretinoin (all-trans retinoic acid, ATRA)
Tretinoin (all-trans retinoic acid, ATRA) approved in US
Induction of remission in APL (t(15;17)/PML-RARA)

1988 · 1

1988MilestoneTretinoin (all-trans retinoic acid, ATRA)
All-trans retinoic acid produces remissions in Shanghai: the first differentiation therapy
A milestone in how this cancer is treated.

1977 · 1

1977MilestoneCytogenetics and karyotype
t(15;17) translocation identified
A milestone in how this cancer is treated.

1957 · 1

1957MilestoneAcute promyelocytic leukaemia
Hillestad describes acute promyelocytic leukaemia
A milestone in how this cancer is treated.