Chronic lymphocytic leukaemia, first treatment

What changed: Chronic lymphocytic leukaemia, first treatment

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Every dated change on the records linked to Chronic lymphocytic leukaemia, first treatment, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Approval3Trial result7Milestone7This record1

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September 2026 · 1

2026-09-17This recordChronic lymphocytic leukaemia, first treatment
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When this page itself was last checked or edited.

2026 · 1

2026ApprovalAcalabrutinib
Acalabrutinib approved in US
Fixed-duration acalabrutinib + venetoclax, previously untreated CLL/SLL without del(17p)/TP53 (AMPLIFY)

2025 · 1

2025MilestoneAMPLIFY
AMPLIFY: acalabrutinib-venetoclax fixed duration in fit patients
A milestone in how this cancer is treated.

2024 · 1

2024Trial resultAMPLIFY
AMPLIFY reported
3-year PFS 76.

2023 · 2

2022 · 2

2021 · 2

2019 · 4

2014 · 1

2014MilestoneIbrutinib
Ibrutinib approved for CLL; obinutuzumab-chlorambucil for unfit patients
A milestone in how this cancer is treated.

2013 · 1

2013ApprovalObinutuzumab
Obinutuzumab approved in US
Previously untreated CLL with chlorambucil (CLL11)

2010 · 1

2010MilestoneFludarabine
CLL8: fludarabine-cyclophosphamide-rituximab lengthens life, the first regimen to do so
A milestone in how this cancer is treated.

1952 · 1

1952MilestoneChlorambucil
Chlorambucil introduced; the standard for forty years
A milestone in how this cancer is treated.