HER2-positive breast cancer with brain metastases

What changed: HER2-positive breast cancer with brain metastases

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Every dated change on the records linked to HER2-positive breast cancer with brain metastases, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Trial result6Milestone8This record1

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September 2026 · 1

2026-09-17This recordHER2-positive breast cancer with brain metastases
Facts on this page last checked
When this page itself was last checked or edited.

2025 · 2

2024 · 2

2023 · 2

2022 · 1

2022MilestoneTrastuzumab deruxtecan
TUXEDO-1 and DEBBRAH: trastuzumab deruxtecan active in the brain
A milestone in how this cancer is treated.

2021 · 1

2021Trial resultDESTINY-Breast03
DESTINY-Breast03 reported
PFS HR 0.

2020 · 1

2020MilestoneHER2CLIMB
HER2CLIMB: tucatinib approved, the first drug proven in active brain metastases
A milestone in how this cancer is treated.

2019 · 1

2019Trial resultHER2CLIMB
HER2CLIMB reported
OS 21.

2016 · 2

2013 · 1

2013MilestoneLapatinib
LANDSCAPE: lapatinib with capecitabine shrinks untreated brain metastases
A milestone in how this cancer is treated.

2003 · 1

2003MilestoneTrastuzumab
Brain as the first site of progression on trastuzumab described
A milestone in how this cancer is treated.