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Cancers
Single-system Langerhans cell histiocytosis (bone, skin or one other organ)
Data

Cancers·Single-system Langerhans cell histiocytosis (bone, skin or one other organ)

DataSingle-system Langerhans cell histiocytosis (bone, skin or one other organ)

Back to the Single-system Langerhans cell histiocytosis hub →24 connected records

Every connected record, the notes, the JSON, Markdown and RDF twins, and where the record came from and when it was checked.

Overview What it is Finding it Treating it Evidence The science Where you are Living with it What is coming Data

Data

Related pages

24

Direct links plus the targets, companies, and technologies of this cancer's products.

Similar pages

not linked directly; found by shared links

Cancer
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Shares Late effects and survivorship toxicity, Ultrasound, Active surveillance, MRI and the tags subtype-page, paediatric.
Cancer
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Shares Late effects and survivorship toxicity, MRI, Cytotoxic chemotherapy and the tags subtype-page, paediatric.
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Shares Late effects and survivorship toxicity and the tags subtype-page, paediatric.
Cancer
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Shares Late effects and survivorship toxicity and the tags subtype-page, paediatric.
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Philadelphia chromosome-positive acute lymphoblastic leukaemia in children (Ph-positive ALL)
Shares Small-molecule kinase inhibitors and the tags subtype-page, paediatric.
Cancer
Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL)
Shares Small-molecule kinase inhibitors and the tags subtype-page, paediatric.
Cancer
High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL)
Shares Cytotoxic chemotherapy and the tags subtype-page, paediatric.
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Shares the tags subtype-page, paediatric.

technologies

7

Active surveillance Cytotoxic chemotherapy FDG PET Histopathology & immunohistochemistry MRI Small-molecule kinase inhibitors Ultrasound

targets

1

drugs

5

ApprovedPurine nucleoside analogue

Cladribine · Leustatin / Litak

ApprovedSmall-molecule kinase inhibitor (MEK1/2)

Cobimetinib · Cotellic

ApprovedSmall-molecule kinase inhibitors (BRAF + MEK)

Dabrafenib + trametinib · Tafinlar + Mekinist

ApprovedSmall-molecule kinase inhibitor (BRAF V600)

Vemurafenib · Zelboraf

ApprovedVinca alkaloid (microtubule inhibitor)

Vinblastine · Velban

companies

4

Eli Lilly (incl. Loxo)Johnson & Johnson Novartis Roche / Genentech

pathways

1

RAS / RAF / MEK / ERK (MAPK)

terms

2

BRAF V600E mutation Late effects and survivorship toxicity

trials

1

key papers

3

LCH-III: therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis Recurrent BRAF mutations in Langerhans cell histiocytosis Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages

Machine-readable versions

The same record for scripts and assistants; checked 2026-09-18. Data CC BY-NC 4.0, attribute “Data from OnCo (onco.cc)”.

JSON with neighbours Markdown context RDF Turtle Sections with routes and counts API root

Not yet reviewedNeeds expert (clinical) and patient advocate review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Key papers for the 39 rare-cancer subtype pages · diff · file

Wikipedia

Langerhans cell histiocytosis

Sources & links

NCI PDQ Langerhans cell histiocytosis
Wikipedia

subtype-page paediatric

Data

JSON · ·

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Machine-readable versions of Single-system Langerhans cell histiocytosis (bone, skin or one other organ)

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All cancers as JSON
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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id lch-single-system.

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