Loading
Micronodular thymoma with lymphoid stroma is a rare, benign-behaving thymoma made of small nests of spindle-shaped epithelial cells separated by abundant B lymphocytes, unlike other thymomas whose lymphocytes are T cells. It is cured by surgery; its curiosity is that a third harbour a clonal B-cell population, and a few develop a low-grade lymphoma within the tumour.
Micronodular thymoma with lymphoid stroma is an uncommon thymoma variant in the WHO classification, characterised by multiple small nodules of type A thymoma-like cells separated by a B-cell-rich lymphoid stroma with follicles (Histopathology 2015). Monoclonal B-cell populations were found in 6 of 18 cases (33 percent), with an intratumoural lymphoma in three, against consistently polyclonal B cells in thymic follicular hyperplasia and other thymomas; the neoplastic epithelium expresses chemokines that recruit dendritic and B cells, setting the stage for lymphoma (Journal of Pathology 2005). Langerhans cells are abundant within the tumour nests and mature dendritic cells cluster with T cells in the stroma, suggesting how the lymphoid follicles form (Histopathology 2015).
How it differs from its parent: its lymphocytes are B rather than immature T cells, myasthenia gravis is rare, behaviour is indolent, and the only complication of note is a MALT-type lymphoma arising within it.
How common: no registry figure; a rare variant (Histopathology 2015).
Treatment: complete resection, which is curative in the reported cases; any associated lymphoma is treated on the MALT lymphoma page; no adjuvant therapy is indicated.
Rare: the two pathology series in the sources read hold 18 and 6 cases (Journal of Pathology 2005; Histopathology 2015). No registry figure exists.
Central tumours arise in the large airways, peripheral ones in the alveoli; both drain to hilar then mediastinal nodes, and the pleural lining is a separate cancer site.
Same organ: Mediastinal germ cell tumour, Pleuropulmonary blastoma (types I, Ir, II and III), Type A and type AB thymoma, Type B1 and type B2 thymoma, Type B3 thymoma, Adenocarcinoma of the lung, Squamous cell carcinoma of the lung, Large cell carcinoma of the lung, Sarcomatoid carcinoma of the lung, Adenosquamous carcinoma of the lung, Invasive mucinous adenocarcinoma of the lung, Adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung, Basaloid squamous cell carcinoma of the lung, Lymphoepithelial carcinoma of the lung, Pulmonary blastoma (adult), Non-small-cell lung cancer, Lung cancer (all types), Small-cell lung cancer, Mesothelioma, Pleural mesothelioma, Thymoma and thymic carcinoma, Childhood lung and airway tumours (pleuropulmonary blastoma, tracheobronchial tumours), Inflammatory myofibroblastic tumour (IMT), EGFR-mutated non-small-cell lung cancer, ALK-positive non-small-cell lung cancer, KRAS G12C-mutant non-small-cell lung cancer, ROS1-positive non-small-cell lung cancer, MET exon 14 and MET-amplified non-small-cell lung cancer, RET fusion-positive non-small-cell lung cancer, BRAF V600E-mutant non-small-cell lung cancer, HER2-mutant non-small-cell lung cancer, NTRK fusion-positive non-small-cell lung cancer, PD-L1-high non-small-cell lung cancer without a driver mutation, Resectable stage I to III non-small-cell lung cancer, Unresectable stage III non-small-cell lung cancer, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Lung neuroendocrine tumours (typical and atypical carcinoid), Thymoma (WHO types A, AB, B1, B2 and B3), Thymic carcinoma
Complete resection; associated lymphoma treated on the MALT lymphoma page; no adjuvant therapy.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this cancer: (TITLE:"Micronodular thymoma with lymphoid stroma" OR ABSTRACT:"Micronodular thymoma with lymphoid stroma" OR TITLE:"Micronodular thymoma" OR ABSTRACT:"Micronodular thymoma" OR TITLE:"MNT" OR ABSTRACT:"MNT" OR TITLE:"Micronodular thymoma with lymphoid stroma rare, indolent" OR ABSTRACT:"Micronodular thymoma with lymphoid stroma rare, indolent" OR TITLE:"Micronodular thymoma with lymphoid stroma thymoma, thymic-epithelial" OR ABSTRACT:"Micronodular thymoma with lymphoid stroma thymoma, thymic-epithelial") AND (treatment OR therapy OR trial OR survival OR diagnosis). Results are unfiltered search hits about Micronodular thymoma with lymphoid stroma, not a curated reading list.
No targets or pathways are linked to this cancer yet. Browse the gene hub →
Cases by country, the UK and NHS pathway and other country lenses, and the expert centres with trials on record.
One section per setting: the options named, what each is for, the trials behind them, the recorded trade-offs and the questions to ask.
Newly diagnosed? Read the first 60 days with Micronodular thymoma with lymphoid stroma, then print the one-page appointment sheet with room for the answers.
Print this page for your appointment (your browser's print command). These prompts are for discussion; your clinical team knows your case.
Everything in development, the open problems and what is being done about them, the roadmaps, and what changed on this record.
Every connected record, the notes, the JSON, Markdown and RDF twins, and where the record came from and when it was checked.