Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)

What changed: Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)

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Every dated change on the records linked to Multiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Trial result1Guideline2Milestone7This record1

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September 2026 · 1

2026-09-10This recordMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Facts on this page last checked
When this page itself was last checked or edited.

2023 · 2

2020 · 1

2020MilestoneSelpercatinib
Selpercatinib and pralsetinib approved for RET-mutant MTC
A milestone in how this cancer is treated.

2015 · 2

2012 · 1

2012GuidelineMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Guideline MEN1 clinical practice guidelines (Thakker, JCEM 2012): MEN1 carriers
Surveillance from childhood; subtotal or total parathyroidectomy with autotransplantation for hyperparathyroidism; proton pump inhibitors for gastrinoma; resection of functioning or larger PanNETs; sporadic NET pathways (somatostatin analogues, everolimus, sunitinib, PRRT) for advanced disease.

1997 · 1

1997MilestoneMenin
MEN1 gene cloned
Chandrasekharappa and colleagues, Science; menin identified.

1993 · 1

1993MilestoneRET
RET mutations cause MEN2A
Mulligan and colleagues, Nature; Donis-Keller and colleagues.

1961 · 1

1961MilestoneMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Sipple describes the association of pheochromocytoma and thyroid carcinoma (MEN2)
A milestone in how this cancer is treated.

1954 · 1

1954MilestoneMultiple endocrine neoplasia syndromes (MEN1, MEN2, MEN4)
Wermer describes familial adenomatosis of endocrine glands (MEN1)
A milestone in how this cancer is treated.