What changed: Retinoblastoma

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Every dated change on the records linked to Retinoblastoma, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Approval1Milestone8This record1

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September 2026 · 1

2026-09-08This recordRetinoblastoma
Facts on this page last checked
When this page itself was last checked or edited.

2020 · 1

2020MilestoneRetinoblastoma
Global Retinoblastoma Study: survival tied to national income (JAMA Oncol)
A milestone in how this cancer is treated.

2017 · 1

2017MilestoneLiquid biopsy (ctDNA)
Aqueous humour as liquid biopsy (Berry)
A milestone in how this cancer is treated.

2012 · 1

2012MilestoneMelphalan (including hepatic delivery system)
Intravitreal melphalan for vitreous seeds (Munier)
A milestone in how this cancer is treated.

2008 · 1

2008MilestoneMelphalan (including hepatic delivery system)
Intra-arterial melphalan via ophthalmic artery (Abramson)
A milestone in how this cancer is treated.

1996 · 1

1996MilestoneCarboplatin
Systemic chemoreduction with focal therapy replaces radiation (Shields, Gallie)
A milestone in how this cancer is treated.

1986 · 1

1986MilestoneTP53
RB1 cloned (Friend, Weinberg, Dryja)
The first tumour-suppressor gene identified.

1971 · 1

1971MilestoneRetinoblastoma
Knudson's two-hit hypothesis
Statistical analysis of hereditary vs sporadic retinoblastoma predicts tumour-suppressor genes.

1959 · 1

1959ApprovalCyclophosphamide
Cyclophosphamide approved in US
Lymphomas, leukaemias, multiple myeloma, breast, ovarian, neuroblastoma, retinoblastoma and other cancers

1809 · 1

1809MilestoneRetinoblastoma
Wardrop recommends enucleation for 'fungus haematodes'
First curative approach.