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Everything in development, the open problems and what is being done about them, the roadmaps, and what changed on this record.
What is in development for Brain metastases (secondary brain tumours), drawn from the whole corpus: 15 items. Drugs are grouped by the most advanced trial phase they have reached anywhere; approved treatments sit under standard of care. Technologies are the methods being tested for this cancer, trials are the studies recorded here, and ideas are proposals not yet in a trial.
Trials still often exclude patients with brain metastases, so drug activity in the brain is learned late.
Nothing recorded yet.
Background: Blood-brain barrier (BBB), HER2-positive brain metastases. Also on OnCo: Atlas of advanced disease · How cancer spreads: the metastasis stages.
Leptomeningeal disease has no standard treatment and a survival of months.
Nothing recorded yet.
Background: Blood-brain barrier (BBB), HER2-positive brain metastases. Also on OnCo: Atlas of advanced disease · How cancer spreads: the metastasis stages.
Radionecrosis after radiosurgery is hard to tell from progression and hard to treat.
Few drugs are designed from the start to cross the blood-brain barrier.
Dated changes read from the records linked to this cancer: approvals, regulatory steps, reported trials, guideline versions and milestones. Newest first; no date is inferred.
On EdgeAll 21 changes by month →When this page itself was last checked or edited.
CNS ORR 71.
A milestone in how this cancer is treated.
HER2+ metastatic breast cancer including brain metastases, with trastuzumab and capecitabine (HER2CLIMB)
HER2+ metastatic breast cancer including brain metastases, with trastuzumab and capecitabine
5-year PFS 60% vs 8%, HR 0.