InSphero, a Swiss spin-off of ETH Zürich, makes tiny three-dimensional balls of human cells that behave more like real tissue than cells grown flat in a dish. Drug developers use its tumour spheroids, made from patients' tumours, to test cancer and immune drugs before trials in people.
InSphero was founded in 2009 as a spin-off from ETH Zürich and has offices in Schlieren, Switzerland, and Brunswick, Maine. It provides 3D in vitro models, microplates (Akura and Gri3D) and organ-on-chip platforms for drug discovery. For oncology and immunology it offers patient-derived primary tumour spheroids, which it says keep the epithelial, immune and stromal components of the original tumour, and models built from genomically characterised patient-derived xenografts, run in Akura 96- and 384-well plates for drug screening and for measuring tumour-immune interactions. In 2025 it signed a definitive agreement to acquire DOPPL SA, and in 2026 it acquired PhenoVista Biosciences of California.
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