OncoC4
OncoC4 is a United States-based biotechnology company running 5 late-stage cancer trials of ONC-392, AI-081 and ONC-392 low in non-small-cell lung cancer, melanoma and head and neck squamous cell carcinoma.
Overview
OncoC4, based in Rockville, MD, the United States, is a biotechnology company. A clinical-stage biotechnology company developing immunotherapies (monoclonal and bispecific antibodies, antibody-drug conjugates) for cancer and Alzheimer's disease, targeting CTLA-4, PD-1/VEGF, Siglec and CD24 pathways; grew out of the founders' prior work at OncoImmune following its acquisition by Merck. On ClinicalTrials.gov it is the lead sponsor of 5 recruiting or active phase 2 and phase 3 interventional cancer trials (1 in phase 3), testing ONC-392, AI-081, ONC-392 low, ONC-392 high and Gotistobart in non-small-cell lung cancer, melanoma, head and neck squamous cell carcinoma, renal cell carcinoma and colorectal cancer. The largest, NCT04140526 (Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumours and NSCLC), plans to enrol 733 participants. Sponsor and trial facts are from the ClinicalTrials.gov registry, checked on 2026-09-11; company facts are from the official website.
Scorecard
All companies- phase 3 +3
- phase 1/2 +1
- targets +6
- modalities +4
Gotistobart is an experimental monoclonal antibody from OncoC4 in phase 3 trials for non-small-cell lung cancer, melanoma and head and neck squamous cell carcinoma, aimed at CTLA-4.
AI-081 is an experimental bispecific antibody from OncoC4 in phase 2 trials, aimed at PD-1 and VEGF / VEGFR.
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