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Vortex Therapeutics
Vortex Therapeutics is an Illinois company making tablets that block MYC, a protein that drives the growth of many cancers and has had no direct drug. Its lead medicine, VOR-001, is being prepared for first trials in people.
Also called: VORTEX THERAPEUTICS INC
Overview
Vortex Therapeutics, of Lombard, Illinois, develops small-molecule inhibitors of intrinsically disordered proteins. Its most advanced programme, VOR-001, is described as a direct, orally bioavailable small-molecule MYC inhibitor that the company has selected to advance to an investigational new drug application; the company reports tumour regression in a hepatocellular carcinoma model in mice and has developed a response signature for selecting patients. In fiscal year 2026 the National Cancer Institute funded its SBIR project on a novel MYC inhibitor for cancer therapy (5R44CA302283-02, USD 1,142,245).
Headquarters
Lombard, IL, US
Scorecard
All companies#698of 1706 companies, score 4
- targets +2
- modalities +2
0 approved, 0 in phase 3, 0 earlier, 1 targets, 0 registry studies. Formula on the scorecards page.
Funding
All startupsStartup
Investors not recorded; see the round sources.
Rounds on record
| Round | Year | Amount | Source |
|---|---|---|---|
| Grant · NCI SBIR (R44) award 5R44CA302283-02: Development of a novel MYC inhibitor for cancer therapy | 2026 | $1M | reporter.nih.gov |
Amounts only where the cited source states them. Rounds without a public source are not listed.
Type
Stage
Startup
Website
Products
1PreclinicalOral small-molecule inhibitor
VOR-001 is an oral medicine from Vortex Therapeutics designed to block the cancer-driving protein MYC directly; it has been tested in animals so far.
Notes
- Read on vortextherapeutics.com (home, science and pipeline pages) and the NIH RePORTER record on 4 November 2026. Efficacy and safety statements are the company's own preclinical findings.
Connected
3Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
vortextherapeutics.com · 2
nih.gov · 1
A source that has moved or gone is reported by the weekly link check. /audit/