ACVR1B
ACVR1B (Activin receptor type-1B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Colorectal cancer, Breast cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Location: Cell membrane (UniProt). Locus 12q13.13 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 4 cohorts (PAAD)
- Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COAD, COADREAD)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)
- Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ACVR1B" OR ABSTRACT:"ACVR1B" OR TITLE:"activin A receptor type 1B" OR ABSTRACT:"activin A receptor type 1B" OR TITLE:"Activin receptor type-1B" OR ABSTRACT:"Activin receptor type-1B" OR TITLE:"ALK4" OR ABSTRACT:"ALK4" OR TITLE:"SKR2" OR ABSTRACT:"SKR2" OR TITLE:"ActRIB" OR ABSTRACT:"ActRIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACVR1B, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/acvr1b.json. Licence CC BY-NC 4.0.