BLM (RecQ-like DNA helicase BLM) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Breast cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA. Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides. Location: Nucleus (UniProt). Locus 15q26.1 (HGNC).
- Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059)
- Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575)
- Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170)
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Endometrial cancer: Open Targets association 0.53 with endometrial cancer (MONDO_0011962)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"BLM" OR ABSTRACT:"BLM" OR TITLE:"BLM RecQ like helicase" OR ABSTRACT:"BLM RecQ like helicase" OR TITLE:"RecQ-like DNA helicase BLM" OR ABSTRACT:"RecQ-like DNA helicase BLM" OR TITLE:"RECQL3" OR ABSTRACT:"RECQL3" OR TITLE:"RECQ2" OR ABSTRACT:"RECQ2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BLM, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/blm.json. Licence CC BY-NC 4.0.