CASP8
CASP8 (Caspase-8) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Skin cancer, Cervical cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood. Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A. The resulting aggregate called the death-inducing signalling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Location: Cytoplasm; Nucleus; Cell projection, lamellipodium (UniProt). Locus 2q33.1 (HGNC).
- Head and neck squamous cell carcinoma: Open Targets association 0.66 with head and neck squamous cell carcinoma (MONDO_0010150); IntOGen driver in 4 cohorts (HNSC)
- Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)
- Cervical cancer: IntOGen driver in 3 cohorts (CEAD, CESC)
- Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)
- Nasopharyngeal carcinoma: IntOGen driver in 2 cohorts (NPC)
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CASP8" OR ABSTRACT:"CASP8" OR TITLE:"caspase 8" OR ABSTRACT:"caspase 8" OR TITLE:"Caspase-8" OR ABSTRACT:"Caspase-8" OR TITLE:"MCH5" OR ABSTRACT:"MCH5" OR TITLE:"FLICE" OR ABSTRACT:"FLICE" OR TITLE:"Casp-8" OR ABSTRACT:"Casp-8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CASP8, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/casp8.json. Licence CC BY-NC 4.0.