CBFA2T3
CBFA2T3 (Transcriptional corepressor CBFA2T3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer, Lung cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Golgi apparatus membrane (UniProt). Locus 16q24.3 (HGNC).
- Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Myeloproliferative neoplasms: Open Targets association 0.50 with myeloproliferative neoplasm (MONDO_0020076)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CBFA2T3" OR ABSTRACT:"CBFA2T3" OR TITLE:"CBFA2/RUNX1 partner transcriptional co-repressor 3" OR ABSTRACT:"CBFA2/RUNX1 partner transcriptional co-repressor 3" OR TITLE:"Transcriptional corepressor CBFA2T3" OR ABSTRACT:"Transcriptional corepressor CBFA2T3" OR TITLE:"MTGR2" OR ABSTRACT:"MTGR2" OR TITLE:"ZMYND4" OR ABSTRACT:"ZMYND4" OR TITLE:"MTG16" OR ABSTRACT:"MTG16") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CBFA2T3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cbfa2t3.json. Licence CC BY-NC 4.0.