CD73 / adenosine axis
CD73 is an enzyme on tumour and immune cells that converts ATP breakdown products into adenosine, a powerful immune-suppressant; blocking it or the adenosine receptors was a major immunotherapy hope that has not yet delivered. This dossier gathers the 0 products (0 approved), 0 trials, 1 pathway and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Ecto-5'-nucleotidase anchored by GPI; produces adenosine that binds Gs-coupled A2A/A2B receptors, raising cAMP/PKA in lymphocytes and blunting TCR signalling, cytokine release and cytotoxicity; also promotes Treg and MDSC function.
- Pancreatic cancer (high CD73)
- NSCLC (especially KRAS/STK11-mutant)
- TNBC, ovarian, colorectal cancer
- Tregs, MDSCs and endothelium in the microenvironment
Elsewhere: identifiers and databases
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes that involve this target
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways where it is a node
Pathway-to-drug matrix →- Nutrient competition & metabolic immunosuppressionNode: CD39 → CD73 → adenosine · 4 druggable nodes
Tumours and immune cells eat from the same plate. Cancer cells hoard glucose and glutamine, dump lactate and acid, and burn tryptophan and arginine into by-products that paralyse T cells. The tumour wins the food fight, and the immune system loses before it has fired a shot.
Which nodes have drugs →
Companion diagnostics and assays
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Key papers and the live literature
Preprints →Query for this target: (TITLE:"CD73 / adenosine axis" OR ABSTRACT:"CD73 / adenosine axis" OR TITLE:"NT5E" OR ABSTRACT:"NT5E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD73 / adenosine axis, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cd73-adenosine.json. Licence CC BY 4.0.