CDKN1B
CDKN1B (Cyclin-dependent kinase inhibitor 1B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer, Prostate cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry. Location: Nucleus; Cytoplasm; Endosome (UniProt). Locus 12p13.1 (HGNC).
- Thyroid cancer: Open Targets association 0.65 with thyroid cancer (MONDO_0002108)
- Prostate cancer: Open Targets association 0.63 with prostate cancer (MONDO_0008315); IntOGen driver in 4 cohorts (PRAD)
- Breast cancer: Open Targets association 0.63 with breast cancer (MONDO_0007254); CIViC evidence names this disease
- Neuroendocrine tumours: Open Targets association 0.62 with neuroendocrine neoplasm (MONDO_0019496)
- Head and neck squamous cell carcinoma: CIViC evidence names this disease
- Multiple myeloma: IntOGen driver in 2 cohorts (PCM)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CDKN1B" OR ABSTRACT:"CDKN1B" OR TITLE:"cyclin dependent kinase inhibitor 1B" OR ABSTRACT:"cyclin dependent kinase inhibitor 1B" OR TITLE:"Cyclin-dependent kinase inhibitor 1B" OR ABSTRACT:"Cyclin-dependent kinase inhibitor 1B" OR TITLE:"KIP1" OR ABSTRACT:"KIP1" OR TITLE:"P27KIP1" OR ABSTRACT:"P27KIP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDKN1B, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cdkn1b.json. Licence CC BY-NC 4.0.