CLTC (Clathrin heavy chain 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Renal cell carcinoma, Hepatocellular carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilisation of kinetochore fibres of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fibre tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilisation of the lattice promoting uncoating. Location: Cytoplasmic vesicle membrane; Membrane, coated pit; Melanosome; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 17q23.1 (HGNC).
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)
- Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)
- Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CLTC" OR ABSTRACT:"CLTC" OR TITLE:"clathrin heavy chain" OR ABSTRACT:"clathrin heavy chain" OR TITLE:"Clathrin heavy chain 1" OR ABSTRACT:"Clathrin heavy chain 1" OR TITLE:"Hc" OR ABSTRACT:"Hc" OR TITLE:"CLTCL2" OR ABSTRACT:"CLTCL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLTC, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cltc.json. Licence CC BY-NC 4.0.