CSNK1E
CSNK1E (Casein kinase I isoform epsilon) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Follicular lymphoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Participates in Wnt signalling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908)
- Follicular lymphoma: Open Targets association 0.52 with follicular lymphoma (MONDO_0018906)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CSNK1E" OR ABSTRACT:"CSNK1E" OR TITLE:"casein kinase 1 epsilon" OR ABSTRACT:"casein kinase 1 epsilon" OR TITLE:"Casein kinase I isoform epsilon" OR ABSTRACT:"Casein kinase I isoform epsilon" OR TITLE:"HCKIE" OR ABSTRACT:"HCKIE" OR TITLE:"CKIepsilon" OR ABSTRACT:"CKIepsilon") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSNK1E, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/csnk1e.json. Licence CC BY-NC 4.0.