ELP1 (Elongator complex protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Medulloblastoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Location: Cytoplasm; Nucleus (UniProt). Locus 9q31.3 (HGNC).
- Medulloblastoma: Open Targets association 0.72 with medulloblastoma (MONDO_0007959)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ELP1" OR ABSTRACT:"ELP1" OR TITLE:"elongator acetyltransferase complex subunit 1" OR ABSTRACT:"elongator acetyltransferase complex subunit 1" OR TITLE:"Elongator complex protein 1" OR ABSTRACT:"Elongator complex protein 1" OR TITLE:"TOT1" OR ABSTRACT:"TOT1" OR TITLE:"IKI3" OR ABSTRACT:"IKI3" OR TITLE:"IKBKAP" OR ABSTRACT:"IKBKAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELP1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/elp1.json. Licence CC BY-NC 4.0.