ERCC2
ERCC2 (General transcription and DNA repair factor IIH helicase subunit XPD) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Skin cancer, Colorectal cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognises damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. Location: Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 19q13.32 (HGNC).
- Bladder & urothelial cancer: Open Targets association 0.73 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease
- Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)
- Melanoma: Open Targets association 0.58 with melanoma (MONDO_0005105); CIViC evidence names this disease
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ERCC2" OR ABSTRACT:"ERCC2" OR TITLE:"ERCC excision repair 2, TFIIH core complex helicase subunit" OR ABSTRACT:"ERCC excision repair 2, TFIIH core complex helicase subunit" OR TITLE:"General transcription and DNA repair factor IIH helicase subunit XPD" OR ABSTRACT:"General transcription and DNA repair factor IIH helicase subunit XPD" OR TITLE:"EM9" OR ABSTRACT:"EM9" OR TITLE:"MGC102762" OR ABSTRACT:"MGC102762" OR TITLE:"MGC126218" OR ABSTRACT:"MGC126218") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ercc2.json. Licence CC BY-NC 4.0.