FKBP12 (FKBP1A)
FKBP12 is the small protein that rapamycin-type drugs grab first; the drug-FKBP12 pair then clamps onto mTOR and switches off its growth signalling. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
An abundant cytosolic immunophilin that also regulates ryanodine and TGF-beta receptors; drug binding, not its own enzyme activity, is what matters for the mTOR effect.
- Ubiquitous, cytosolic
- Required for the action of everolimus, temsirolimus and sirolimus
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"FKBP12" OR ABSTRACT:"FKBP12" OR TITLE:"FKBP1A" OR ABSTRACT:"FKBP1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FKBP12 (FKBP1A), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/fkbp12.json. Licence CC BY-NC 4.0.