HGF (Hepatocyte growth factor) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Gastric & gastro-oesophageal junction cancer, Skin cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerisation. Activates MAPK signalling following TMPRSS13 cleavage and activation. Locus 7q21.11 (HGNC).
- Lung cancer: Open Targets association 0.62 with lung cancer (MONDO_0008903)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.59 with gastric cancer (MONDO_0001056)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
- Glioma & glioblastoma: CIViC evidence names this disease
- Small-cell lung cancer: IntOGen driver in 1 cohort (SCLC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"HGF" OR ABSTRACT:"HGF" OR TITLE:"hepatocyte growth factor" OR ABSTRACT:"hepatocyte growth factor" OR TITLE:"Hepatocyte growth factor" OR ABSTRACT:"Hepatocyte growth factor" OR TITLE:"F-TCF" OR ABSTRACT:"F-TCF" OR TITLE:"DFNB39" OR ABSTRACT:"DFNB39") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HGF, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hgf.json. Licence CC BY-NC 4.0.