KRT18
KRT18 (Keratin, type I cytoskeletal 18) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Structural component of intermediate filaments in simple epithelial cells. Forms intermediate filaments by heterodimerising with the type II keratin KRT8, providing mechanical stability and resilience to epithelial cells. Involved in ARHGEF40-mediated actin stress fibre formation and tensional force-induced stress fibre formation and reinforcement. Integrates into the intermediate filament network of skeletal muscle fibres alongside desmin and KRT19, contributing to force transmission. Organisation and orientation of KRT8/KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules. Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading. Location: Nucleus matrix; Cytoplasm, perinuclear region; Nucleus, nucleolus; Cytoplasm (UniProt). Locus 12q13.13 (HGNC).
- Prostate cancer: CIViC evidence names this disease
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"KRT18" OR ABSTRACT:"KRT18" OR TITLE:"keratin 18" OR ABSTRACT:"keratin 18" OR TITLE:"Keratin, type I cytoskeletal 18" OR ABSTRACT:"Keratin, type I cytoskeletal 18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KRT18, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/krt18.json. Licence CC BY-NC 4.0.