MUC16 (CA-125)
The giant mucin that is shed into blood as the CA-125 ovarian cancer marker; its membrane stalk is being targeted by ADCs and T-cell engagers. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
22,000-amino-acid mucin with tandem repeats, SEA domains cleaved to release CA-125, and a short cytoplasmic tail; mediates immune evasion (binds Siglec-9, mesothelin), adhesion to mesothelium and metastasis.
- High-grade serous ovarian cancer (~80%)
- Pancreatic adenocarcinoma (~65%)
- Endometrial, lung adenocarcinoma, mesothelioma
- Serum CA-125 in ovarian cancer monitoring
Elsewhere: identifiers and databases
Built from HGNC, Ensembl, UniProt and ChEMBL idsHow common it is, by cancer
Full matrix →| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Ovarian cancer | 80% | MUC16 expression | doi.org |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Products by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes that involve this target
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways where it is a node
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics and assays
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Key papers and the live literature
Preprints →Query for this target: (TITLE:"MUC16" OR ABSTRACT:"MUC16" OR TITLE:"CA-125" OR ABSTRACT:"CA-125") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUC16 (CA-125), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/muc16.json. Licence CC BY 4.0.