NCOR2
NCOR2 (Nuclear receptor corepressor 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Hepatocellular carcinoma, Prostate cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal centre (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signalling and androgen-induced cell proliferation. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Location: Nucleus (UniProt). Locus 12q24.31 (HGNC).
- Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD)
- Hepatocellular carcinoma: IntOGen driver in 2 cohorts (HCC)
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315); IntOGen driver in 1 cohort (PRAD)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)
- Sarcomas: IntOGen driver in 1 cohort (LMS)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"NCOR2" OR ABSTRACT:"NCOR2" OR TITLE:"nuclear receptor corepressor 2" OR ABSTRACT:"nuclear receptor corepressor 2" OR TITLE:"Nuclear receptor corepressor 2" OR ABSTRACT:"Nuclear receptor corepressor 2" OR TITLE:"SMRTE" OR ABSTRACT:"SMRTE" OR TITLE:"TRAC-1" OR ABSTRACT:"TRAC-1" OR TITLE:"CTG26" OR ABSTRACT:"CTG26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOR2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ncor2.json. Licence CC BY-NC 4.0.