NFATC2
NFATC2 (Nuclear factor of activated T-cells, cytoplasmic 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Breast cancer, Skin cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signalling pathway. Is involved in the negative regulation of chondrogenesis. Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signalling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signalling and activation of NFAT-dependent transcriptional responses. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.2 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Rectal cancer: IntOGen driver in 1 cohort (READ)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"NFATC2" OR ABSTRACT:"NFATC2" OR TITLE:"nuclear factor of activated T cells 2" OR ABSTRACT:"nuclear factor of activated T cells 2" OR TITLE:"Nuclear factor of activated T-cells, cytoplasmic 2" OR ABSTRACT:"Nuclear factor of activated T-cells, cytoplasmic 2" OR TITLE:"NF-ATP" OR ABSTRACT:"NF-ATP" OR TITLE:"NFATp" OR ABSTRACT:"NFATp" OR TITLE:"NFAT1" OR ABSTRACT:"NFAT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFATC2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nfatc2.json. Licence CC BY-NC 4.0.