Progesterone receptor (PGR)
The progesterone receptor is the hormone receptor that, alongside the oestrogen receptor, marks breast cancers likely to respond to hormone therapy, and it is the target of the progestins megestrol and medroxyprogesterone used in endometrial and breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
PGR encodes two isoforms, PR-A and PR-B, from alternative promoters; the receptor binds progesterone, dimerises and regulates transcription at progesterone response elements, and it cross-talks with the oestrogen receptor at shared chromatin sites. In breast cancer PR expression is a marker of ER activity and of luminal A biology; loss of PR in an ER-positive tumour predicts a poorer response to endocrine therapy. In the endometrium progesterone opposes oestrogen-driven proliferation, which is why unopposed oestrogen causes endometrial cancer and progestins treat it.
- Breast epithelium and most ER-positive breast cancers
- Endometrium and endometrial cancers
- Ovary, uterus and brain
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
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Literature
Preprints →Query for this target: (TITLE:"Progesterone receptor" OR ABSTRACT:"Progesterone receptor" OR TITLE:"PGR" OR ABSTRACT:"PGR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Progesterone receptor (PGR), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pgr.json. Licence CC BY-NC 4.0.