PIK3R1
PIK3R1 (Phosphatidylinositol 3-kinase regulatory subunit alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Colorectal cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signalling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signalling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. Location: Cytoplasm (UniProt). Locus 5q13.1 (HGNC).
- Endometrial cancer: Open Targets association 0.71 with endometrial cancer (MONDO_0011962); IntOGen driver in 4 cohorts (UCEC)
- Colorectal cancer: Open Targets association 0.68 with colorectal cancer (MONDO_0005575); CIViC evidence names this disease
- Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254); CIViC evidence names this disease
- Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)
- Sarcomas: CIViC evidence names this disease
- Gastric & gastro-oesophageal junction cancer: IntOGen driver in 2 cohorts (STAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PIK3R1" OR ABSTRACT:"PIK3R1" OR TITLE:"phosphoinositide-3-kinase regulatory subunit 1" OR ABSTRACT:"phosphoinositide-3-kinase regulatory subunit 1" OR TITLE:"Phosphatidylinositol 3-kinase regulatory subunit alpha" OR ABSTRACT:"Phosphatidylinositol 3-kinase regulatory subunit alpha" OR TITLE:"GRB1" OR ABSTRACT:"GRB1" OR TITLE:"p85-ALPHA" OR ABSTRACT:"p85-ALPHA" OR TITLE:"p85" OR ABSTRACT:"p85") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PIK3R1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pik3r1.json. Licence CC BY-NC 4.0.