PIK3R3
PIK3R3 (Phosphatidylinositol 3-kinase regulatory subunit gamma) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Locus 1p34.1 (HGNC).
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PIK3R3" OR ABSTRACT:"PIK3R3" OR TITLE:"phosphoinositide-3-kinase regulatory subunit 3" OR ABSTRACT:"phosphoinositide-3-kinase regulatory subunit 3" OR TITLE:"Phosphatidylinositol 3-kinase regulatory subunit gamma" OR ABSTRACT:"Phosphatidylinositol 3-kinase regulatory subunit gamma" OR TITLE:"p55" OR ABSTRACT:"p55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PIK3R3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pik3r3.json. Licence CC BY-NC 4.0.