PTCH1 (Patched 1)
PTCH1 is the brake on the hedgehog growth pathway. When it is lost, as in nearly all basal cell carcinomas and in Gorlin syndrome, the pathway runs unchecked; vismodegib and sonidegib put the brake back one step down, at smoothened. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
A tumour suppressor rather than a druggable target: PTCH1 inactivation is what makes a tumour hedgehog-dependent and so eligible for SMO antagonists. The hedgehog pathway record notes resistance through SMO mutations or SUFU and GLI2 alterations downstream.
- Basal cell carcinoma (PTCH1 loss in nearly all cases)
- SHH-subgroup medulloblastoma
- Gorlin (basal cell nevus) syndrome (germline PTCH1 loss)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PTCH1" OR ABSTRACT:"PTCH1" OR TITLE:"Patched 1" OR ABSTRACT:"Patched 1" OR TITLE:"PTCH" OR ABSTRACT:"PTCH" OR TITLE:"NBCCS" OR ABSTRACT:"NBCCS" OR TITLE:"patched 1" OR ABSTRACT:"patched 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTCH1 (Patched 1), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ptch1.json. Licence CC BY-NC 4.0.